Mackanin is meeting with the media at Fenway Park on Monday night.
Mackanin is looking to replace Terry Francona, who parted ways with the team after its unprecedented September collapse. Mackanin also spent time in the Expos, Pirates, Reds and Yankees systems.
He was an interim manager with the Reds in 2007 and the Pirates in 2005, going 53-53 in the two temporary gigs. He is also 917-849 in 13 years as a minor league manager.
Also Monday, the Red Sox declined contract options on relievers Dan Wheeler and Scott Atchison.
Sabathia agrees to new deal to stay with Yankees
Sabathia had until midnight to opt out of his current contract, which had $92 million remaining over the next four years in $23 million annual salaries.
The new deal adds a $25 million salary for 2016 and gives the Yankees a $25 million option for 2017 with a $5 million buyout, a person familiar with the agreement told The Associated Press. The person spoke on condition of anonymity because the Yankees had not yet announced the deal.
Sabathia agreed to a $161 million, seven-year deal with New York before the 2009 season.